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Review
. 2007 Dec;31(6):753-7.
doi: 10.1007/s00264-007-0417-7. Epub 2007 Jul 5.

Newly reported roles of thyroid-stimulating hormone and follicle-stimulating hormone in bone remodelling

Rebecca A Sendak  1 , T Kuber Sampath, John M McPherson
Affiliations
Review

Newly reported roles of thyroid-stimulating hormone and follicle-stimulating hormone in bone remodelling

Rebecca A Sendak et al. Int Orthop. 2007 Dec.

Abstract
in English, French

Thyroid-stimulating hormone (TSH) and follicle-stimulating hormone (FSH) have both been recently implicated in bone remodelling. Clinical evidence, as well as data from TSH receptor and thyroid hormone receptor knockout mice, suggest that TSH has a direct effect on skeletal homeostasis, although some data are conflicting. Recently, the exogenous administration of TSH has been shown to positively impact bone in oophrectomised rats. These data, along with their potential implications for the treatment of severe osteoporosis, are discussed.

L’ATSH et la FSH sont impliquées de façon conjointe dans le remodelage osseux. Il est évident que sur le plan clinique et après analyse des données, la stimulation des récepteurs hormonaux de l’hormone thyroïdienne a un effet direct sur l’homéostasie osseuse. Récemment, il a été montré que l’utilisation d’hormones thyroïdiennes avait également un effet positif sur l’os des rats ovariectomisés. Toutes ces données et leurs conséquences thérapeutiques sont discutées dans les cas d’ostéoporoses sévères.

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Figures

Fig. 1
Fig. 1
Hypothalamic pituitary axis. For both systems, the hypothalamus secretes releasing hormones that act on the pituitary gland. In response, the pituitary gland releases follicle-stimulating hormone (FSH) or thyroid-stimulating hormone (TSH). FSH and TSH then act at remote sites to induce endocrine effects. Adapted from Alcohol Health & Research World 1998; 22(3):153–164
Fig. 2
Fig. 2
Reduced bone mineral density (BMD) in TSHR −/− and +/− mice. A PIXImus (Lunar) bone densitometer was used to measure the BMD at specified sites. Reprinted from Cell 2003; 115:151–162 with permission from Elsevier
Fig. 3
Fig. 3
Micro computed tomography (CT) measurement of distal femurs in rats treated with rat TSH at doses from 0.01 to 0.3 μg for 4 months and 7 months following rat oophrectomy (OVX). a Micro CT images of horizontal sections from distal femurs. b All doses of TSH increased the trabecular bone volume (BV/TV), trabecular number (Tr.Nm.), trabecular thickness (Tr.Th.) and decreased the trabecular separation (Tr.Sp.), trabecular pattern formation (Tr.pf) and structural model index (SMI) (0-plate to 3-rode). Data are mean±SEM. *Significantly different from group OVX (ANOVA/Dunnett test, P<0.05). n=12 for all groups. Reproduced from J Bone Miner Res 2007 (in press) with permission from the American Society for Bone and Mineral Research (ASBMR)
See this image and copyright information in PMC

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