Review
doi: 10.1093/hmg/ddm021.
Cancer genetics of epigenetic genes
Affiliations
- PMID: 17613546
- DOI: 10.1093/hmg/ddm021
Item in Clipboard
Review
Cancer genetics of epigenetic genes
Hum Mol Genet.
.
Abstract
The cancer epigenome is characterised by specific DNA methylation and chromatin modification patterns. The proteins that mediate these changes are encoded by the epigenetics genes here defined as: DNA methyltransferases (DNMT), methyl-CpG-binding domain (MBD) proteins, histone acetyltransferases (HAT), histone deacetylases (HDAC), histone methyltransferases (HMT) and histone demethylases. We review the evidence that these genes can be targeted by mutations and expression changes in human cancers.
Similar articles
-
Expression analysis of the epigenetic methyltransferases and methyl-CpG binding protein families in the normal B-cell and B-cell chronic lymphocytic leukemia (CLL).Cancer Biol Ther. 2004 Oct;3(10):989-94. doi: 10.4161/cbt.3.10.1137. Epub 2004 Oct 2. Cancer Biol Ther. 2004. PMID: 15467427
-
Lung cancer and its association with chronic obstructive pulmonary disease: update on nexus of epigenetics.Curr Opin Pulm Med. 2011 Jul;17(4):279-85. doi: 10.1097/MCP.0b013e3283477533. Curr Opin Pulm Med. 2011. PMID: 21537190 Free PMC article. Review.
-
Differential expression of selected histone modifier genes in human solid cancers.BMC Genomics. 2006 Apr 25;7:90. doi: 10.1186/1471-2164-7-90. BMC Genomics. 2006. PMID: 16638127 Free PMC article.
-
Effect of dynamic DNA methylation and histone acetylation on cPouV expression in differentiation of chick embryonic germ cells.Stem Cells Dev. 2013 Oct 15;22(20):2725-35. doi: 10.1089/scd.2013.0046. Epub 2013 Jul 17. Stem Cells Dev. 2013. PMID: 23750509 Free PMC article.
-
Dynamic protein methylation in chromatin biology.Cell Mol Life Sci. 2009 Feb;66(3):407-22. doi: 10.1007/s00018-008-8303-z. Cell Mol Life Sci. 2009. PMID: 18923809 Free PMC article. Review.
Cited by
-
Turning on the Radio: Epigenetic Inhibitors as Potential Radiopriming Agents.Biomolecules. 2016 Jul 4;6(3):32. doi: 10.3390/biom6030032. Biomolecules. 2016. PMID: 27384589 Free PMC article. Review.
-
miRNAs Copy Number Variations Repertoire as Hallmark Indicator of Cancer Species Predisposition.Genes (Basel). 2022 Jun 10;13(6):1046. doi: 10.3390/genes13061046. Genes (Basel). 2022. PMID: 35741808 Free PMC article.
-
Epimutation and Cancer: Carcinogenesis Viewed as Error-Prone Inheritance of Epigenetic Information.J Oncol. 2018 Jun 3;2018:2645095. doi: 10.1155/2018/2645095. eCollection 2018. J Oncol. 2018. PMID: 29971105 Free PMC article. Review.
-
SET oncoprotein accumulation regulates transcription through DNA demethylation and histone hypoacetylation.Oncotarget. 2017 Apr 18;8(16):26802-26818. doi: 10.18632/oncotarget.15818. Oncotarget. 2017. PMID: 28460463 Free PMC article.
-
Histone Deacetylase Inhibitors: Advancing Therapeutic Strategies in Hematological and Solid Malignancies.Pharmaceuticals (Basel). 2010 Aug 1;3(8):2411-2469. doi: 10.3390/ph3082441. Pharmaceuticals (Basel). 2010. PMID: 21151768 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
