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. 2007 Jun;13(6):498-501.

[Voltage-dependent anion channels (VDAC) on human sperm membrane]

[Article in Chinese]
Zeng-jun Wang  1 , Wei Zhang, Hong-fei Wu, Yuan-geng Sui
Affiliations
  • PMID: 17615971

[Voltage-dependent anion channels (VDAC) on human sperm membrane]

[Article in Chinese]
Zeng-jun Wang et al. Zhonghua Nan Ke Xue. 2007 Jun.

Abstract

Objective: To further study gene expression and characterization of voltage-dependent anion channels (VDACs) on human spermatozoa.

Methods: VDACs were cloned by PCR from the testis cDNA library. Recombinant human sperm VDACs were produced in E. coli system by molecular cloning technology. Sperm membrane protein was extracted by 1% Triton X-100 and separated by chloroform/methanol.

Results: The gene expression of VDACs was found in the human testis cDNA library and VDAC protein was detected located on the sperm membrane by alpha-helix.

Conclusion: VDAC proteins, abundant on the human sperm membrane and responsible for anion transportation, play an important role in sperm signaling transduction and fertility.

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