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Randomized Controlled Trial
. 2007 Sep;16(7):1137-46.
doi: 10.1007/s11136-007-9219-z. Epub 2007 Jul 7.

The effect of walking and vitamin B supplementation on quality of life in community-dwelling adults with mild cognitive impairment: a randomized, controlled trial

Jannique G Z van Uffelen  1 , Marijke J M Chin A Paw, Marijke Hopman-Rock, Willem van Mechelen
Affiliations
Randomized Controlled Trial

The effect of walking and vitamin B supplementation on quality of life in community-dwelling adults with mild cognitive impairment: a randomized, controlled trial

Jannique G Z van Uffelen et al. Qual Life Res. 2007 Sep.

Abstract

Objectives: To examine the effect of walking and vitamin B supplementation on quality-of-life (QoL) in community-dwelling adults with mild cognitive impairment.

Methods: One year, double-blind, placebo-controlled trial. Participants were randomized to: (1) twice-weekly, group-based, moderate-intensity walking program (n = 77) or a light-intensity placebo activity program (n = 75); and (2) daily vitamin B pills containing 5 mg folic acid, 0.4 mg B12, 50 mg B6 (n = 78) or placebo pills (n = 74). QoL was measured at baseline, after six and 12 months using the population-specific Dementia Quality-of-Life (D-QoL) to assess overall QoL and the generic Short-Form 12 mental and physical component scales (SF12-MCS and SF12-PCS) to assess health-related QoL.

Results: Baseline levels of QoL were relatively high. Modified intention-to-treat analyses revealed no positive main intervention effect of walking or vitamin supplementation. In both men and women, ratings of D-QoL-belonging and D-QoL-positive affect subscales improved with 0.003 (P = 0.04) and 0.002 points (P = 0.06) with each percent increase in attendance to the walking program. Only in men, SF12-MCS increased with 0.03 points with each percent increase in attendance (P = 0.08).

Conclusion: Several small but significant improvements in QoL were observed with increasing attendance to the walking program. No effect of vitamin B supplementation was observed.

Trial registration: International Standard Randomized Controlled Trial Number Register, 19227688, http://www.controlled-trials.com/isrctn/.

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Figures

Fig. 1
Fig. 1
Flow chart. TI = Telephone Interview, WP = Walking Program, PAP = Placebo Activity Program, FA/B12/B6 = Folic Acid, Vitamin B12, Vitamin B6 supplementation, SO = significant other, T6 = follow-up after 6 months, T12= follow-up after 12 months, *reason for exclusion: only baseline data available
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