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Randomized Controlled Trial
. 2007 Sep;16(7):1137-46.
doi: 10.1007/s11136-007-9219-z. Epub 2007 Jul 7.

The effect of walking and vitamin B supplementation on quality of life in community-dwelling adults with mild cognitive impairment: a randomized, controlled trial

Jannique G Z van Uffelen  1 , Marijke J M Chin A Paw, Marijke Hopman-Rock, Willem van Mechelen
Affiliations
Randomized Controlled Trial

The effect of walking and vitamin B supplementation on quality of life in community-dwelling adults with mild cognitive impairment: a randomized, controlled trial

Jannique G Z van Uffelen et al. Qual Life Res. 2007 Sep.

Abstract

Objectives: To examine the effect of walking and vitamin B supplementation on quality-of-life (QoL) in community-dwelling adults with mild cognitive impairment.

Methods: One year, double-blind, placebo-controlled trial. Participants were randomized to: (1) twice-weekly, group-based, moderate-intensity walking program (n = 77) or a light-intensity placebo activity program (n = 75); and (2) daily vitamin B pills containing 5 mg folic acid, 0.4 mg B12, 50 mg B6 (n = 78) or placebo pills (n = 74). QoL was measured at baseline, after six and 12 months using the population-specific Dementia Quality-of-Life (D-QoL) to assess overall QoL and the generic Short-Form 12 mental and physical component scales (SF12-MCS and SF12-PCS) to assess health-related QoL.

Results: Baseline levels of QoL were relatively high. Modified intention-to-treat analyses revealed no positive main intervention effect of walking or vitamin supplementation. In both men and women, ratings of D-QoL-belonging and D-QoL-positive affect subscales improved with 0.003 (P = 0.04) and 0.002 points (P = 0.06) with each percent increase in attendance to the walking program. Only in men, SF12-MCS increased with 0.03 points with each percent increase in attendance (P = 0.08).

Conclusion: Several small but significant improvements in QoL were observed with increasing attendance to the walking program. No effect of vitamin B supplementation was observed.

Trial registration: International Standard Randomized Controlled Trial Number Register, 19227688, http://www.controlled-trials.com/isrctn/.

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Figures

Fig. 1
Fig. 1
Flow chart. TI = Telephone Interview, WP = Walking Program, PAP = Placebo Activity Program, FA/B12/B6 = Folic Acid, Vitamin B12, Vitamin B6 supplementation, SO = significant other, T6 = follow-up after 6 months, T12= follow-up after 12 months, *reason for exclusion: only baseline data available
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References

    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1001/archneur.56.3.303', 'is_inner': False, 'url': 'https://doi.org/10.1001/archneur.56.3.303'}, {'type': 'PubMed', 'value': '10190820', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/10190820/'}]}
    2. Petersen, R. C., Smith, G. E., Waring, S. C., Ivnik, R. J., Tangalos, E. G., & Kokmen, E. (1999). Mild cognitive impairment: clinical characterization and outcome. Archives Neurology, 56, 303–308. - PubMed
    1. Mol, M., Carpay, M., Ramakers, I., Rozendaal, N., Verhey, F., & Jolles, J. (2006). The effect of perceived forgetfulness on quality of life in older adults; a qualitative review. International Journal of Geriatric Psychiatry. - PubMed
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'PubMed', 'value': '10843352', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/10843352/'}]}
    2. Frisoni, G. B., Fratiglioni, L., Fastbom, J., Guo, Z., Viitanen, M., & Winblad, B. (2000). Mild cognitive impairment in the population and physical health: data on 1,435 individuals aged 75–95. Journals of Gerontology Series A-Biological Sciences and Medical Sciences, 55, M322–M328. - PubMed
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'PubMed', 'value': '7671024', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/7671024/'}]}
    2. Gill, T. M., Richardson, E. D., & Tinetti, M. E. (1995). Evaluating the risk of dependence in activities of daily living among community-living older adults with mild to moderate cognitive impairment. Journals of Gerontology Series A-Biological Sciences and Medical Sciences, 50: M235–M241. - PubMed
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'PubMed', 'value': '15462464', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/15462464/'}]}
    2. Borowiak, E., & Kostka, T. (2004). Predictors of quality of life in older people living at home and in institutions. Aging Clinical Experimental Research, 16, 212–220. - PubMed

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