Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2007 Sep;16(7):1137-46.
doi: 10.1007/s11136-007-9219-z. Epub 2007 Jul 7.

The effect of walking and vitamin B supplementation on quality of life in community-dwelling adults with mild cognitive impairment: a randomized, controlled trial

Jannique G Z van Uffelen  1 , Marijke J M Chin A Paw, Marijke Hopman-Rock, Willem van Mechelen
Affiliations
Randomized Controlled Trial

The effect of walking and vitamin B supplementation on quality of life in community-dwelling adults with mild cognitive impairment: a randomized, controlled trial

Jannique G Z van Uffelen et al. Qual Life Res. 2007 Sep.

Abstract

Objectives: To examine the effect of walking and vitamin B supplementation on quality-of-life (QoL) in community-dwelling adults with mild cognitive impairment.

Methods: One year, double-blind, placebo-controlled trial. Participants were randomized to: (1) twice-weekly, group-based, moderate-intensity walking program (n = 77) or a light-intensity placebo activity program (n = 75); and (2) daily vitamin B pills containing 5 mg folic acid, 0.4 mg B12, 50 mg B6 (n = 78) or placebo pills (n = 74). QoL was measured at baseline, after six and 12 months using the population-specific Dementia Quality-of-Life (D-QoL) to assess overall QoL and the generic Short-Form 12 mental and physical component scales (SF12-MCS and SF12-PCS) to assess health-related QoL.

Results: Baseline levels of QoL were relatively high. Modified intention-to-treat analyses revealed no positive main intervention effect of walking or vitamin supplementation. In both men and women, ratings of D-QoL-belonging and D-QoL-positive affect subscales improved with 0.003 (P = 0.04) and 0.002 points (P = 0.06) with each percent increase in attendance to the walking program. Only in men, SF12-MCS increased with 0.03 points with each percent increase in attendance (P = 0.08).

Conclusion: Several small but significant improvements in QoL were observed with increasing attendance to the walking program. No effect of vitamin B supplementation was observed.

Trial registration: International Standard Randomized Controlled Trial Number Register, 19227688, http://www.controlled-trials.com/isrctn/.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Flow chart. TI = Telephone Interview, WP = Walking Program, PAP = Placebo Activity Program, FA/B12/B6 = Folic Acid, Vitamin B12, Vitamin B6 supplementation, SO = significant other, T6 = follow-up after 6 months, T12= follow-up after 12 months, *reason for exclusion: only baseline data available
See this image and copyright information in PMC

References

    1. Petersen, R. C., Smith, G. E., Waring, S. C., Ivnik, R. J., Tangalos, E. G., & Kokmen, E. (1999). Mild cognitive impairment: clinical characterization and outcome. Archives Neurology, 56, 303–308. - DOI - PubMed
    1. Mol, M., Carpay, M., Ramakers, I., Rozendaal, N., Verhey, F., & Jolles, J. (2006). The effect of perceived forgetfulness on quality of life in older adults; a qualitative review. International Journal of Geriatric Psychiatry. - PubMed
    1. Frisoni, G. B., Fratiglioni, L., Fastbom, J., Guo, Z., Viitanen, M., & Winblad, B. (2000). Mild cognitive impairment in the population and physical health: data on 1,435 individuals aged 75–95. Journals of Gerontology Series A-Biological Sciences and Medical Sciences, 55, M322–M328. - PubMed
    1. Gill, T. M., Richardson, E. D., & Tinetti, M. E. (1995). Evaluating the risk of dependence in activities of daily living among community-living older adults with mild to moderate cognitive impairment. Journals of Gerontology Series A-Biological Sciences and Medical Sciences, 50: M235–M241. - PubMed
    1. Borowiak, E., & Kostka, T. (2004). Predictors of quality of life in older people living at home and in institutions. Aging Clinical Experimental Research, 16, 212–220. - PubMed

Publication types

MeSH terms

Substances

Associated data