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. 2008 Feb;32(2):309-14.
doi: 10.1016/j.leukres.2007.05.013. Epub 2007 Jul 6.

Bone marrow pre-B expansion by SL/Kh-Bomb1 locus: not sufficient for lymphomagenesis

Takuya Hiratsuka  1 , Tatsuaki Tsuruyama, Richard Kaszynski, Kohei Kometani, Nagahiro Minato, Takuro Nakamura, Keiji Tamaki, Hiroshi Hiai
Affiliations

Bone marrow pre-B expansion by SL/Kh-Bomb1 locus: not sufficient for lymphomagenesis

Takuya Hiratsuka et al. Leuk Res. 2008 Feb.

Abstract

The pre-B lymphoma in SL/Kh mice is a polygenic trait involving a number of host genes. In prelymphoma-stage bone marrow, transient pre-B cell expansion is induced by a host locus, Bomb1, and later followed by the emergence of a monoclonal population with a similar phenotype. To determine whether these pre-B cells represent precursors of lymphomas, we generated a congenic strain, NFS.SL/Kh-Bomb1 mice, by marker-assisted backcrossing to NFS. The congenic mice showed pre-B cell expansion, but pre-B lymphomas were not observed, even after 1 year of observation, irrespective of murine leukemia virus inoculation. Disturbed early B cell differentiation per se is not sufficient for SL/Kh lymphomagenesis.

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