Comment
doi: 10.1016/j.leukres.2007.05.016.
Epub 2007 Jul 6.
Modern prognostic factors and angiogenesis in chronic lymphocytic leukemia: more data needed
Affiliations
- PMID: 17617454
- DOI: 10.1016/j.leukres.2007.05.016
Item in Clipboard
Comment
Modern prognostic factors and angiogenesis in chronic lymphocytic leukemia: more data needed
Leuk Res.
2007 Dec.
Abstract
Angiogenesis appears to be an important player in biology of chronic lymphocytic leukemia (CLL). We present here data on association of ZAP-70 expression measured by flow cytometry and plasma levels of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in 27 untreated CLL patients. We found significantly higher VEGF (but not bFGF) in ZAP-negative patients. Likewise, there was a negative correlation between percentage of ZAP-70 expression and VEGF. Larger, prospective studies are needed to confirm our pilot data.
Comment on
-
Markers of increased angiogenesis and their correlation with biological parameters identifying high-risk patients in early B-cell chronic lymphocytic leukemia.Leuk Res. 2007 Nov;31(11):1575-8. doi: 10.1016/j.leukres.2007.03.009. Epub 2007 May 7. Leuk Res. 2007. PMID: 17485110
Similar articles
-
[Basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF) are elevated in peripheral blood plasma of patients with chronic lymphocytic leukemia and decrease after intensive fludarabine-based treatment].Vnitr Lek. 2007 Nov;53(11):1171-6. Vnitr Lek. 2007. PMID: 18277626 Czech.
-
Markers of increased angiogenesis and their correlation with biological parameters identifying high-risk patients in early B-cell chronic lymphocytic leukemia.Leuk Res. 2007 Nov;31(11):1575-8. doi: 10.1016/j.leukres.2007.03.009. Epub 2007 May 7. Leuk Res. 2007. PMID: 17485110
-
Circulating endothelial cells in patients with chronic lymphocytic leukemia.Ann Hematol. 2008 May;87(5):369-73. doi: 10.1007/s00277-007-0435-y. Epub 2008 Jan 12. Ann Hematol. 2008. PMID: 18193423
-
Angiogenesis in non-small cell lung cancer: the prognostic impact of neoangiogenesis and the cytokines VEGF and bFGF in tumours and blood.Lung Cancer. 2006 Feb;51(2):143-58. doi: 10.1016/j.lungcan.2005.09.005. Epub 2005 Dec 19. Lung Cancer. 2006. PMID: 16360975 Review.
-
[ZAP-70 in B-cell chronic lymphocytic leukemia: clinical significance and methods of detection].Vnitr Lek. 2006 Dec;52(12):1194-9. Vnitr Lek. 2006. PMID: 17299914 Review. Czech.
Cited by
-
Proteomic characterization of HIV-modulated membrane receptors, kinases and signaling proteins involved in novel angiogenic pathways.J Transl Med. 2009 Aug 27;7:75. doi: 10.1186/1479-5876-7-75. J Transl Med. 2009. PMID: 19712456 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials
