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Clinical Trial
. 2007 Jul 6:6:88.
doi: 10.1186/1475-2875-6-88.

Intermittent preventive treatment with sulphadoxine-pyrimethamine is effective in preventing maternal and placental malaria in Ibadan, south-western Nigeria

Catherine O Falade  1 , Bidemi O Yusuf, Francis F Fadero, Olugbenga A Mokuolu, Davidson H Hamer, Lateef A Salako
Affiliations
Clinical Trial

Intermittent preventive treatment with sulphadoxine-pyrimethamine is effective in preventing maternal and placental malaria in Ibadan, south-western Nigeria

Catherine O Falade et al. Malar J. .

Abstract

Background: Intermittent preventive treatment with sulphadoxine-pyrimethamine (IPT-SP) is currently the recommended regimen for prevention of malaria in pregnancy in endemic areas. This study sets out to evaluate the effectiveness of IPT-SP in the prevention of maternal and placental malaria in parturient mothers in Ibadan, Nigeria, where the risk of malaria is present all year round.

Method: During a larger study evaluating the epidemiology of congenital malaria, the effect of malaria prophylaxis was examined in 983 parturient mothers. Five hundred and ninety eight mothers (60.8%) received IPT-SP, 214 (21.8%) received pyrimethamine (PYR) and 171 (17.4%) did not take any chemoprophylactic agent (NC).

Results: The prevalence of maternal parasitaemia in the IPT-SP, PYR and NC groups was 10.4%, 15.9% and 17% respectively (p = 0.021). The prevalence of placental parasitaemia was 10.5% in the IPT-SP, 16.8% PYR and 17% NC groups, respectively (p = 0.015). The prevalence of maternal anaemia (haematocrit <30%) was 5.7% vs. 8.9% vs. 13.4% among the IPT-SP, PYR and NC groups respectively (p < 0.0001) while that of pre-term delivery (GA <37 weeks) was 10.5%, 19.2% and 25.3% among IPT-SP, PYR and NC groups respectively (p < 0.0001). Babies born to mothers in the IPT-SP, PYR and NC groups had mean birth weights of 3204 +/- 487.16, 3075 +/- 513.24 and 3074 +/- 505.92 respectively (rho < 0.0001). There was a trend towards a lower proportion of low birth weight babies in the IPT-SP group (p = 0.095).

Conclusion: IPT-SP is effective in preventing maternal and placental malaria as well as improving pregnancy outcomes among parturient women in Ibadan, Nigeria. The implementation of the recently adopted IPT-SP strategy should be pursued with vigour as it holds great promise for reducing the burden of malaria in pregnancy in Nigeria.

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References

    1. Bray RS, Anderson MJ. Falciparum malaria and pregnancy. Trans R Soc Trop Med Hyg. 1979;73:427–431. doi: 10.1016/0035-9203(79)90170-6. - DOI - PubMed
    1. Brabin BJ. An analysis of malaria in pregnancy in Africa. Bull World Health Organ. 1983;61:1005–1016. - PMC - PubMed
    1. Cot M, Abel L, Roisin A, Barro D, Yada A, Carnevale P, Feingold J. Risk factors of malaria infection during pregnancy in Burkina Faso: Suggestion of a genetic influence. Am J Trop Med Hyg. 1993;48:358–364. - PubMed
    1. Akanbi OM, Odaibo AB, Afolabi KA, Ademowo OG. Effect of self-medication with antimalarial drugs on malaria infection in pregnant women in South-Western Nigeria. Med Princ Pract. 2005;14:6–9. doi: 10.1159/000081915. - DOI - PubMed
    1. WHO . A Strategic framework for malaria prevention and control during pregnancy in the African region. 01. Brazzaville: WHO Regional Office for Africa; 2004.

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