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Editorial
. 2007;9(3):107.
doi: 10.1186/bcr1735.

Estrogen receptor-beta: why may it influence clinical outcome in estrogen receptor-alpha positive breast cancer?

Margaret A Shupnik
Editorial

Estrogen receptor-beta: why may it influence clinical outcome in estrogen receptor-alpha positive breast cancer?

Margaret A Shupnik. Breast Cancer Res. 2007.

Abstract

In the previous issue of the journal, Lin and coworkers present data demonstrate that increased expression of estrogen receptor (ER)-beta in ER-alpha-positive breast cancer cells antagonizes a defined group of ER-alpha/estrogen stimulated genes that are involved in cell cycle regulation and DNA replication. Similar expression patterns for these genes were found human ER-alpha positive breast tumors expressing higher levels or ER-beta, and this correlated with better clinical outcome. The implications for these data, which suggest that ER-beta is a positive actor and diagnostic marker for therapeutic outcome, are discussed.

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