Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2007 Nov;34(11):1765-74.
doi: 10.1007/s00259-007-0478-2. Epub 2007 Jul 7.

Quantification of myocardial blood flow with 82Rb dynamic PET imaging

Affiliations

Quantification of myocardial blood flow with 82Rb dynamic PET imaging

Mireille Lortie et al. Eur J Nucl Med Mol Imaging. 2007 Nov.

Abstract

Purpose: The PET tracer (82)Rb is commonly used to evaluate regional perfusion defects for the diagnosis of coronary artery disease. There is limited information on the quantification of myocardial blood flow and flow reserve with this tracer. The goal of this study was to investigate the use of a one-compartment model of (82)Rb kinetics for the quantification of myocardial blood flow.

Methods: Fourteen healthy volunteers underwent rest and dipyridamole stress imaging with both (13)N-ammonia and (82)Rb within a 2-week interval. Myocardial blood flow was estimated from the time-activity curves measured with (13)N-ammonia using a standard two-compartment model. The uptake parameter of the one-compartment model was estimated from the time-activity curves measured with (82)Rb. To describe the relationship between myocardial blood flow and the uptake parameter, a nonlinear extraction function was fitted to the data. This function was then used to convert estimates of the uptake parameter to flow estimates. The extraction function was validated with an independent data set obtained from 13 subjects with documented evidence of coronary artery disease (CAD).

Results: The one-compartment model described (82)Rb kinetics very well (median R-square = 0.98). The flow estimates obtained with (82)Rb were well correlated with those obtained with (13)N-ammonia (r = 0.85), and the best-fit line did not differ significantly from the identity line. Data obtained from the subjects with CAD confirmed the validity of the estimated extraction function.

Conclusion: It is possible to obtain accurate estimates of myocardial blood flow and flow reserve with a one-compartment model of (82)Rb kinetics and a nonlinear extraction function.

PubMed Disclaimer

References

    1. J Nucl Med. 1997 Apr;38(4):660-7 - PubMed
    1. Circulation. 1996 Jan 15;93(2):238-45 - PubMed
    1. Curr Pharm Des. 2005;11(7):903-32 - PubMed
    1. Am J Cardiol. 1992 Feb 15;69(5):445-8 - PubMed
    1. J Nucl Med. 1983 Oct;24(10 ):898-906 - PubMed

Publication types

Substances

LinkOut - more resources