Review
doi: 10.1111/j.1365-2982.2007.00964.x.
Importance of 5-hydroxytryptamine receptors on intestinal afferents in the regulation of visceral sensitivity
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- PMID: 17620083
- DOI: 10.1111/j.1365-2982.2007.00964.x
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Review
Importance of 5-hydroxytryptamine receptors on intestinal afferents in the regulation of visceral sensitivity
Neurogastroenterol Motil.
2007 Aug.
Abstract
Serotonin (5-HT) plays an important role as a signalling molecule in the gastrointestinal (GI) tract. The regulation of GI sensitivity via 5-HT is mediated by specific 5-HT receptor subytypes on intrinsic and extrinsic afferents. This review discusses visceral afferent hypersensitivity in irritable bowel syndrome (IBS) and the importance of 5HT(3), 5HT(4), and 5HT(2B) receptor-mediated mechanisms in the regulation of visceral sensitivity.
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