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Review
. 2007 Aug:19 Suppl 2:13-8.
doi: 10.1111/j.1365-2982.2007.00964.x.

Importance of 5-hydroxytryptamine receptors on intestinal afferents in the regulation of visceral sensitivity

B Greenwood-van Meerveld  1
Affiliations
Review

Importance of 5-hydroxytryptamine receptors on intestinal afferents in the regulation of visceral sensitivity

B Greenwood-van Meerveld. Neurogastroenterol Motil. 2007 Aug.

Abstract

Serotonin (5-HT) plays an important role as a signalling molecule in the gastrointestinal (GI) tract. The regulation of GI sensitivity via 5-HT is mediated by specific 5-HT receptor subytypes on intrinsic and extrinsic afferents. This review discusses visceral afferent hypersensitivity in irritable bowel syndrome (IBS) and the importance of 5HT(3), 5HT(4), and 5HT(2B) receptor-mediated mechanisms in the regulation of visceral sensitivity.

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