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. 2007 Jun 15;8(2):Article 44.
doi: 10.1208/pt0802044.

Effect of oppositely charged polymer and dissolution medium on swelling, erosion, and drug release from chitosan matrices

Kiran S Bhise  1 , Ravindra S Dhumal, Bhaskar Chauhan, Anant Paradkar, Shivajirao S Kadam
Affiliations

Effect of oppositely charged polymer and dissolution medium on swelling, erosion, and drug release from chitosan matrices

Kiran S Bhise et al. AAPS PharmSciTech. .

Abstract

The reasons for retarded release of naproxen sodium from the chitosan matrices at different pH include poor aqueous solubility of drug, the formation of a rate-limiting polymer gel barrier along the periphery of matrices, the interaction of naproxen sodium with protonated amino groups of chitosan, and the interaction of ionized amino groups of chitosan with ionized sulfate groups of kappa-carrageenan.

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