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Randomized Controlled Trial
. 2007;34(2):160-5.

Systemic and myocardial inflammation in traditional and off-pump cardiac surgery

Gokcen Orhan  1 , Murat Sargin, Sahin Senay, Meral Yuksel, Erol Kurc, Muge Tasdemir, Batuhan Ozay, Serap Aykut Aka
Affiliations
Randomized Controlled Trial

Systemic and myocardial inflammation in traditional and off-pump cardiac surgery

Gokcen Orhan et al. Tex Heart Inst J. 2007.

Abstract

In this study, we attempted to determine the role of off-pump coronary artery bypass grafting (CABG) in the myocardial and systemic inflammatory responses. Twenty patients who underwent elective CABG were enrolled in this study. Ten patients underwent on-pump CABG, and 10 patients underwent off-pump CABG. There were no differences between patients in preoperative clinical variables. We took systemic venous blood samples for the measurement of tumor necrosis factor-alpha, the MB isoenzyme of creatine kinase (CK-MB), and cardiac troponin I, and we took myocardial biopsies from the interventricular septum for chemiluminescence assay of reactive oxygen species (hydroxyl, hydrogen peroxide, hypochlorite, and superoxide). There was no significant difference in the myocardial tissue release of hydrogen peroxide, hydroxyl, hypochlorite, and superoxide between the 2 groups (P > 0.05). The systemic tumor necrosis factor-alpha levels in the off-pump group were significantly lower than in the on-pump group (P <0.01). The cardiac troponin I and creatine kinase-MB levels at 6, 12, and 24 postoperative hours were not statistically different between the 2 groups (P >0.05). We conclude that off-pump CABG appears to reduce systemic inflammation, without reducing myocardial oxidative stress and inflammation.

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Figures

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Fig. 1 Tumor necrosis factor-α levels in on-pump and off-pump groups. postop = postoperatively
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Fig. 2 Myocardial inflammatory markers in on-pump and off-pump groups. CL = chemiluminescence; rlu = relative light unit
See this image and copyright information in PMC

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References

    1. Penttila HJ, Lepojarvi MV, Kiviluoma KT, Kuakoranta PK, Hassinen IE, Peuhkurinen KF. Myocardial preservation during coronary surgery with and without cardiopulmonary bypass. Ann Thorac Surg 2001;71:565–71. - PubMed
    1. Gundry SR, Romano MA, Shattuck OH, Razzouk AJ, Bailey LL. Seven-year follow-up of coronary artery bypasses performed with and without cardiopulmonary bypass. J Thorac Cardiovasc Surg 1998;115:1273–8. - PubMed
    1. Matata BM, Sosnowski AW, Galinanes M. Off-pump bypass graft operation significantly reduces oxidative stress and inflammation. Ann Thorac Surg 2000;69:785–91. - PubMed
    1. Alwan K, Falcoz PE, Alwan J, Mouawad W, Oujaimi G, Chocron S, Etievent JP. Beating versus arrested heart coronary revascularization: evaluation by cardiac troponin I release. Ann Thorac Surg 2004;77:2051–5. - PubMed
    1. Misoph M, Babin-Ebell J. Interindividual variations in cytokine levels following cardiopulmonary bypass. Heart Vessels 1997;12:119–27. - PubMed

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