Review
doi: 10.1007/s10549-007-9641-5.
Epub 2007 Jul 12.
The role of cyclooxygenase-2 in breast cancer: review
Affiliations
- PMID: 17624587
- DOI: 10.1007/s10549-007-9641-5
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Review
The role of cyclooxygenase-2 in breast cancer: review
Breast Cancer Res Treat.
2008 May.
Abstract
There is a growing body of evidence that COX-2 expression s a fundamental step in breast cancer pathogenesis acting through prostaglandin-dependent and independent mechanisms. Epidemiological studies suggest that NSAIDs confer a moderate degree of benefit against breast cancer. However further work is required to establish how this enzyme system can be best manipulated for therapeutic benefit.
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