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Review
. 2008 May;109(2):189-98.
doi: 10.1007/s10549-007-9641-5. Epub 2007 Jul 12.

The role of cyclooxygenase-2 in breast cancer: review

Gurpreet Singh-Ranger  1 , Mohamed Salhab, Kefah Mokbel
Affiliations
Review

The role of cyclooxygenase-2 in breast cancer: review

Gurpreet Singh-Ranger et al. Breast Cancer Res Treat. 2008 May.

Abstract

There is a growing body of evidence that COX-2 expression s a fundamental step in breast cancer pathogenesis acting through prostaglandin-dependent and independent mechanisms. Epidemiological studies suggest that NSAIDs confer a moderate degree of benefit against breast cancer. However further work is required to establish how this enzyme system can be best manipulated for therapeutic benefit.

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