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Review
. 2007 Sep;43(13):1895-904.
doi: 10.1016/j.ejca.2007.05.021. Epub 2007 Jul 10.

The insulin-like growth factor 1 receptor in cancer: old focus, new future

Hermien Hartog  1 , Jelle Wesseling, H Marike Boezen, Winette T A van der Graaf
Affiliations
Review

The insulin-like growth factor 1 receptor in cancer: old focus, new future

Hermien Hartog et al. Eur J Cancer. 2007 Sep.

Abstract

The importance of insulin-like growth factor 1 receptor (IGF-1R) signalling in malignant behaviour of tumour cells is well established. Currently, development of drugs targeting the IGF-1R as anticancer treatment is emerging. Several IGF-1R targeting strategies are being investigated in phases I and II clinical trials. Interactions of IGF-1R with insulin receptor, however, might complicate efficiency and tolerability of such drugs. This review describes mechanisms, recent developments and potential limitations of IGF-1R antibodies and tyrosine kinase inhibitors.

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