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. 2007 Aug 3;72(16):6290-3.
doi: 10.1021/jo071031g. Epub 2007 Jul 11.

A concise asymmetric synthesis of torcetrapib

Meritxell Guinó  1 , Pim Huat Phua, Jean-Claude Caille, King Kuok Mimi Hii
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A concise asymmetric synthesis of torcetrapib

Meritxell Guinó et al. J Org Chem. .

Abstract

Optically active torcetrapib was synthesized in seven steps from achiral precursors without the need for protecting groups, utilizing an enantioselective aza-Michael reaction to achieve asymmetry.

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