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. 2007 Sep;14(9):1239-41.
doi: 10.1128/CVI.00185-07. Epub 2007 Jul 11.

Follow-up study of tuberculosis-exposed supermarket customers with negative tuberculin skin test results in association with positive gamma interferon release assay results

Willeke P J Franken  1 , Ben F P J Koster, Ailko W J Bossink, Steven F T Thijsen, John J M Bouwman, Jaap T van Dissel, Sandra M Arend
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Follow-up study of tuberculosis-exposed supermarket customers with negative tuberculin skin test results in association with positive gamma interferon release assay results

Willeke P J Franken et al. Clin Vaccine Immunol. 2007 Sep.

Abstract

We report a follow-up study of 29 subjects with negative tuberculin skin test (TST) results in association with positive gamma interferon release assay (IGRA) results, mainly due to responses to CFP-10 in the T-SPOT.TB assay, during a contact investigation. One year later, 12/29 subjects (41%) had converted to positive TST results in association with negative IGRA results.

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Figures

FIG. 1.
FIG. 1.
(A) TST responses in 2005 and 2006. *, 10 subjects with TST results of 0 mm at both time points; dotted line, cutoff value for a positive test. (B) Time course of individual spot counts for ESAT-6 (test panel A) and CFP-10 (test panel B) of the TSPOT.TB assays in 2005 and 2006. Dotted line, the cutoff value for a positive test. Nil, spots obtained in the medium-stimulated well.
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