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Review
. 2007 Jul 14;335(7610):77-9.
doi: 10.1136/bmj.39225.677708.80.

Decline in effectiveness of antenatal corticosteroids with time to birth: real or artefact?

Simon Gates  1 , Peter Brocklehurst
Affiliations
Review

Decline in effectiveness of antenatal corticosteroids with time to birth: real or artefact?

Simon Gates et al. BMJ. .

Abstract

The widely accepted notion that the benefits of antenatal corticosteroids decline with time to birth may not be correct, argue Simon Gates and Peter Brocklehurst, as the evidence is based on unsound subgroup analyses

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Conflict of interest statement

Competing interests: None declared.

Provenance and peer review: Non-commissioned; externally peer reviewed.

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Different types of subgroup analysis. When subgroup analysis is classified by a variable known at randomisation (top), the composition of the intervention group and control group in each subgroup is determined by randomisation. When subgroup analysis is classified by a variable determined after randomisation (bottom), the composition of the two groups is determined by the presence or absence of outcome 1
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