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. 2007 Aug;9(4):335-9.
doi: 10.1016/j.jfms.2007.05.003. Epub 2007 Jul 12.

Clinical effects and outcome of feline permethrin spot-on poisonings reported to the Veterinary Poisons Information Service (VPIS), London

Nicholas M Sutton  1 , Nicola Bates, Alexander Campbell
Affiliations

Clinical effects and outcome of feline permethrin spot-on poisonings reported to the Veterinary Poisons Information Service (VPIS), London

Nicholas M Sutton et al. J Feline Med Surg. 2007 Aug.

Abstract

Permethrin is a pyrethroid insecticide used in dermally applied spot-on flea treatments for dogs. Permethrin-based spot-on preparations are contraindicated in cats because of the high risk of toxicosis. The Veterinary Poisons Information Service (VPIS) is a 24-h access telephone service that provides veterinary professionals in the United Kingdom with information on the management of poisoned animals. In a review of 286 cases reported to the VPIS regarding inappropriate feline exposure to permethrin spot-on (PSO) preparations, 96.9% were symptomatic. Increased muscular activity (as evidenced by twitching, tremor, muscle fasciculations or convulsions) was common and occurred in 87.8% of cases. The duration of increased muscle activity was long, with convulsions lasting on average 38.9 h and tremors 32 h. Recovery typically occurred within 2 to 3 days but in some cases took 5 to 7 days. Death occurred in 10.5% of cases.

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