Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2007 Aug;19(4):394-401.
doi: 10.1016/j.ceb.2007.05.001. Epub 2007 Jul 12.

Lysosome-related organelles: driving post-Golgi compartments into specialisation

Graça Raposo  1 , Michael S Marks, Daniel F Cutler
Affiliations
Review

Lysosome-related organelles: driving post-Golgi compartments into specialisation

Graça Raposo et al. Curr Opin Cell Biol. 2007 Aug.

Abstract

Some cells harbour specialised lysosome-related organelles (LROs) that share features of late endosomes/lysosomes but are functionally, morphologically and/or compositionally distinct. Ubiquitous trafficking machineries cooperate with cell type specific cargoes to produce these organelles. Several genetic diseases are caused by dysfunctional LRO formation and/or motility. Many genes affected by these diseases have been recently identified, revealing new cellular components of the trafficking machinery. Current research reveals how the products of these genes cooperate to generate LROs and how these otherwise diverse organelles are related by the mechanisms through which they form.

PubMed Disclaimer

Figures

Figure 1
Figure 1
LROs display different morphological features A: Melanosomes; B: Azurophilic granules; C: Cytolytic granules; D: MHC class II compartments (Here MIICs are immunogold labeled for MHC class II molecules); E: Weibel Palade Bodies
Figure 2
Figure 2
Comparative biogenesis of Melanosomes and Weibel-Palade Bodies This figure shows both the differences; origin in the TGN versus origin in the EE for these two organelles, and the similarities; continued receipt of content after initial formation (Tyrosinase versus CD63), and recruitment of Rabs. The overall image of a complex, multi-stage, gradual transformation of a post-Golgi (TGN versus EE) organelle into an LRO is similar for both. Gold coating, AP-1; Purple coating, AP-3; Grey coating on stage I melanosome, bilayered clathrin/Hrs coat. TGN, Trans-Golgi Network; EE, early endosome; MVB, multivesicular body/Late endosome; Tyr, Tyrosinase. Tyrp1, Tyrosinase Related Protein-1
See this image and copyright information in PMC

References

    1. Raposo G, Marks MS. The dark side of lysosome-related organelles: specialization of the endocytic pathway for melanosome biogenesis. Traffic. 2002;3:237–248. - PubMed
    1. Bonifacino JS. Insights into the biogenesis of lysosome-related organelles from the study of the Hermansky-Pudlak syndrome. Ann N Y Acad Sci. 2004;1038:103–114. - PubMed
    1. Stinchcombe J, Bossi G, Griffiths GM. Linking albinism and immunity: the secrets of secretory lysosomes. Science. 2004;305:55–59. - PubMed
    1. Holt OJ, Gallo F, Griffiths GM. Regulating secretory lysosomes. J Biochem (Tokyo) 2006;140:7–12. - PubMed
    1. Marks MS, Seabra MC. The melanosome: membrane dynamics in black and white. Nat Rev Mol Cell Biol. 2001;2:738–748. - PubMed

Publication types