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. 2007 Jul 24;581(18):3512-6.
doi: 10.1016/j.febslet.2007.06.075. Epub 2007 Jul 5.

Chronic lung inflammation in aging mice

Kazutetsu Aoshiba  1 , Atsushi Nagai
Affiliations
Free article

Chronic lung inflammation in aging mice

Kazutetsu Aoshiba et al. FEBS Lett. .
Free article

Abstract

To determine whether aging is associated with a pro-inflammatory shift in the lung, inflammation and inflammation-related gene expression in the lungs of 12-week-old and 24-month-old Balb/c mice were studied. cDNA microarray and quantitative reverse transcription-polymerase chain reaction analyses showed that eight inflammation-related genes, including CD20, Burkitt lymphoma receptor 1, CXCR-3, provirus integration site for Moloney murine leukemia virus-2, CD72, IL-8RB, C-Fgr, and CD8beta, were upregulated in the aged mice. Immunohistochemistry showed that the lungs of the aged mice contained increased numbers of CD4 cells, CD8 cells, B cells and macrophages. These results suggest that a pro-inflammatory shift occurs in the lungs of mice with aging.

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