Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1991 Dec 25;19(24):6793-7.
doi: 10.1093/nar/19.24.6793.

cDNA cloning of the HMGI-C phosphoprotein, a nuclear protein associated with neoplastic and undifferentiated phenotypes

G Manfioletti  1 , V Giancotti, A Bandiera, E Buratti, P Sautière, P Cary, C Crane-Robinson, B Coles, G H Goodwin
Affiliations
Free PMC article

cDNA cloning of the HMGI-C phosphoprotein, a nuclear protein associated with neoplastic and undifferentiated phenotypes

G Manfioletti et al. Nucleic Acids Res. .
Free PMC article

Abstract

The HMGI-C protein is a nuclear phosphoprotein expressed at high levels in transformed cells. The cDNA encoding the mouse protein has been isolated and the sequence of the encoded protein shows that it is related to the HMGY and I proteins, proteins which bind in the minor groove of DNA containing stretches of A and T. The HMGI-C protein has three short highly basic domains, an acidic C-terminal domain, and potential CDC2/p34 and casein kinase II phosphorylation sites. Analysis of mRNA levels demonstrate that the HMGI-C gene is not expressed in a variety of mouse tissues but is expressed in Lewis lung carcinoma cells.

PubMed Disclaimer

References

    1. Nature. 1990 Apr 26;344(6269):830-6 - PubMed
    1. Nature. 1990 Apr 5;344(6266):517-22 - PubMed
    1. Cell. 1984 Jul;37(3):889-901 - PubMed
    1. Biochemistry. 1990 Jul 3;29(26):6295-302 - PubMed
    1. Mol Cell Biol. 1991 Jul;11(7):3642-51 - PubMed

Publication types