Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1991 Dec 15;88(24):11037-41.
doi: 10.1073/pnas.88.24.11037.

Magnetic field tomography of coherent thalamocortical 40-Hz oscillations in humans

U Ribary  1 , A A Ioannides, K D Singh, R Hasson, J P Bolton, F Lado, A Mogilner, R Llinás
Affiliations

Magnetic field tomography of coherent thalamocortical 40-Hz oscillations in humans

U Ribary et al. Proc Natl Acad Sci U S A. .

Abstract

This paper introduces the use of magnetic field tomography (MFT), a noninvasive technique based on distributed source analysis of magnetoencephalography data, which makes possible the three-dimensional reconstruction of dynamic brain activity in humans. MFT has a temporal resolution better than 1 msec and a spatial accuracy of 2-5 mm at the cortical level, which deteriorates to 1-3 cm at depths of 6 cm or more. MFT is used here to visualize the origin of a spatiotemporally organized pattern of coherent 40-Hz electrical activity. This coherence, initially observed during auditory input, was proposed to be generated by recurrent corticothalamic oscillation. In support of this hypothesis, we illustrate well-defined 40-Hz coherence between cortical-subcortical sites with a time shift that is consistent with thalamocortical conduction times. Studies on Alzheimer patients indicate that, while a similar activity pattern is present, the cortical component is reduced in these subjects.

PubMed Disclaimer

References

    1. Electroencephalogr Clin Neurophysiol. 1991 Mar;78(3):185-96 - PubMed
    1. Proc Natl Acad Sci U S A. 1991 May 15;88(10):4396-400 - PubMed
    1. Proc Natl Acad Sci U S A. 1991 Feb 1;88(3):897-901 - PubMed
    1. Electroencephalogr Clin Neurophysiol. 1987 Jun;66(6):539-46 - PubMed
    1. Proc Natl Acad Sci U S A. 1989 Mar;86(5):1698-702 - PubMed

Publication types