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. 2007 Jul 31;21(12):1641-3.
doi: 10.1097/QAD.0b013e32823bc9b7.

Enhanced and resumed GB virus C replication in HIV-1-infected individuals receiving HAART

Per Björkman  1 , Leo Flamholc, Vilma Molnegren, Aline Marshall, Nuray Güner, Anders Widell
Affiliations

Enhanced and resumed GB virus C replication in HIV-1-infected individuals receiving HAART

Per Björkman et al. AIDS. .

Abstract

In patients co-infected with HIV-1 and GB virus C (GBV-C), the disappearance of GBV-C RNA has been associated with accelerated disease progression. We studied longitudinal GBV-C viral titres in 28 HIV-1/GVB-C co-infected individuals receiving HAART. During HAART, median GBV-C RNA titres increased from 95 to 6000 copies/ml (P < 0.001). In patients interrupting HAART, GBV-C-RNA titres decreased as HIV replication resumed. These findings further support the theory that GBV-C replication could depend on the dynamics of HIV progression.

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