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. 2007 Jul;70(1):13-8.
doi: 10.1111/j.1747-0285.2007.00534.x.

Nanoparticles featuring amino acid-functionalized side chains as DNA receptors

Partha S Ghosh  1 , Gang Han, Belma Erdogan, Olga Rosado, Sai Archana Krovi, Vincent M Rotello
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Nanoparticles featuring amino acid-functionalized side chains as DNA receptors

Partha S Ghosh et al. Chem Biol Drug Des. 2007 Jul.

Abstract

A family of nanoparticles has been fabricated featuring cationic amino acid-based side chains. This controlled surface modification provides a tool to investigate the effect of various non-covalent interactions at the nanoparticle-DNA interface. The binding affinities of these nanoparticles towards DNA were determined using fluorescence, exhibiting more than threefold modulation in binding a 37-mer DNA strand. The secondary structure of the DNA strand was distorted upon nanoparticle binding, with the extent of distortion dependent on the structure of amino acid side chain.

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