A social deafferentation hypothesis for induction of active schizophrenia
- PMID: 17631618
- PMCID: PMC2632342
- DOI: 10.1093/schbul/sbm079
A social deafferentation hypothesis for induction of active schizophrenia
Abstract
The "social brain" of humans reflects widespread neural resources dedicated to understanding the conversational language, emotionality, states of mind, and intentions of other persons. A social deafferentation (SDA) hypothesis for induction of active schizophrenia is proposed. Analogous to hallucinations produced by sensory deafferentation, such as phantom limb, the SDA hypothesis assumes that high levels of social withdrawal/isolation in vulnerable individuals prompt social cognition programs to produce spurious social meaning in the form of complex, emotionally compelling hallucinations and delusions representing other persons or agents. Arguments against the SDA hypothesis are discussed, and predictions deriving from the hypothesis are offered.
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References
-
- Barton RA. Evolution of the social brain. In: Whiten A, editor. Machiavellian Intelligence. Vol. II. Cambridge: Cambridge University Press; 1997.
-
- Adolphs R. Cognitive neuroscience of human social behaviour. Nat Rev Neurosci. 2003;4:165–178. - PubMed
-
- Blakemore S-J. Social cognitive neuroscience: where are we heading? Trends Cogn Sci. 2004;8:216–222. - PubMed
-
- Insel TR. How the brain processes social information: searching for the social brain. Annu Rev Neurosci. 2004;27:697–722. - PubMed
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