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Review
. 2007 Jul 13;130(1):21-4.
doi: 10.1016/j.cell.2007.06.034.

PP2A: unveiling a reluctant tumor suppressor

Marc Mumby  1
Affiliations
Free article
Review

PP2A: unveiling a reluctant tumor suppressor

Marc Mumby. Cell. .
Free article

Abstract

Although evidence has suggested that the serine/threonine protein phosphatase 2A (PP2A) might be a tumor suppressor protein, it has been difficult to pin down its role in tumor suppression because it acts in a wide variety of signaling pathways. Recent findings, including work in this issue by Junttila et al. (2007), provide convincing evidence that suppression of PP2A activity cooperates with other oncogenic changes to cause transformation of multiple cell types.

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Comment on

  • CIP2A inhibits PP2A in human malignancies.
    Junttila MR, Puustinen P, Niemelä M, Ahola R, Arnold H, Böttzauw T, Ala-aho R, Nielsen C, Ivaska J, Taya Y, Lu SL, Lin S, Chan EK, Wang XJ, Grènman R, Kast J, Kallunki T, Sears R, Kähäri VM, Westermarck J. Junttila MR, et al. Cell. 2007 Jul 13;130(1):51-62. doi: 10.1016/j.cell.2007.04.044. Cell. 2007. PMID: 17632056

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