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. 2007 Jul 16:3:28.
doi: 10.1186/1746-160X-3-28.

Micro-morphologic changes around biophysically-stimulated titanium implants in ovariectomized rats

Kivanc Akca  1 , Ebru Sarac, Ugur Baysal, Mete Fanuscu, Ting-Ling Chang, Murat Cehreli
Affiliations

Micro-morphologic changes around biophysically-stimulated titanium implants in ovariectomized rats

Kivanc Akca et al. Head Face Med. .

Abstract

Background: Osteoporosis may present a risk factor in achievement of osseointegration because of its impact on bone remodeling properties of skeletal phsiology. The purpose of this study was to evaluate micro-morphological changes in bone around titanium implants exposed to mechanical and electrical-energy in osteoporotic rats.

Methods: Fifteen 12-week old sprague-dowley rats were ovariectomized to develop osteoporosis. After 8 weeks of healing period, two titanium implants were bilaterally placed in the proximal metaphyses of tibia. The animals were randomly divided into a control group and biophysically-stimulated two test groups with five animals in each group. In the first test group, a pulsed electromagnetic field (PEMF) stimulation was administrated at a 0.2 mT 4 h/day, whereas the second group received low-magnitude high-frequency mechanical vibration (MECHVIB) at 50 Hz 14 min/day. Following completion of two week treatment period, all animals were sacrificed. Bone sites including implants were sectioned, removed en bloc and analyzed using a microCT unit. Relative bone volume and bone micro-structural parameters were evaluated for 144 mum wide peri-implant volume of interest (VOI).

Results: Mean relative bone volume in the peri-implant VOI around implants PEMF and MECHVIB was significantly higher than of those in control (P < .05). Differences in trabecular-thickness and -separation around implants in all groups were similar (P > .05) while the difference in trabecular-number among test and control groups was significant in all VOIs (P < .05).

Conclusion: Biophysical stimulation remarkably enhances bone volume around titanium implants placed in osteoporotic rats. Low-magnitude high-frequency MECHVIB is more effective than PEMF on bone healing in terms of relative bone volume.

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Figures

Figure 1
Figure 1
Fabricated custom-made device to deliver PEMF stimulation on osteoporotic rats.
Figure 2
Figure 2
Plexiglass bordered vibrating plate used to administer mechanical low-magnitude high-frequency to osteoporotic rats.
Figure 3
Figure 3
3a and 3b. 3-D microCT view of a titanium implant (a) and illustration of defined peri-implant VOIs (b).)
Figure 4
Figure 4
3-D microCT view of VOI 1–3 (from left to right) around control (top), PEMF-stimulated (middle), and MECHVIB-stimulated (bottom) implants.
See this image and copyright information in PMC

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