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Review
. 2007 Oct;81(19):10209-19.
doi: 10.1128/JVI.00872-07. Epub 2007 Jul 18.

Human immunodeficiency virus type 1 subtype distribution in the worldwide epidemic: pathogenetic and therapeutic implications

L Buonaguro  1 , M L Tornesello, F M Buonaguro
Affiliations
Review

Human immunodeficiency virus type 1 subtype distribution in the worldwide epidemic: pathogenetic and therapeutic implications

L Buonaguro et al. J Virol. 2007 Oct.
No abstract available

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Figures

FIG. 1.
FIG. 1.
Evolutionary relationships among nonrecombinant HIV-1 strains. The phylogenetic tree shows HIV-1 groups M, O, and N and subtypes and CRFs within the M group. The phylogenetic analysis was performed on nearly full-length sequences and is based on the neighbor-joining method. The internal branches defining a subtype have been estimated from 1,000 bootstrap replicates.
FIG. 2.
FIG. 2.
Mosaic structure of HIV-1 CRFs. All CRFs that have been described to date are shown (modified from http://www.hiv.lanl.gov/content/hiv-db/CRFs/CRFs.html). The letters and graphic patterns represent the different subtypes of HIV-1 involved in the recombination events. U, unknown.
FIG. 3.
FIG. 3.
Global prevalence of HIV-1 genetic forms. The global prevalence of each form, expressed as a percentage of the total number of HIV-1 isolates identified worldwide, is shown. Isolates from HIV-1 groups O and N were not included in this analysis.
FIG. 4.
FIG. 4.
Global geographical distribution of HIV-1 genetic forms. Genetic forms predominant in different world regions are shown. The pie charts show the prevalence of individual genetic forms in each region.
FIG. 5.
FIG. 5.
Phylogenetic tree of primate lentivirus sequences. Phylogenetic tree analysis was performed by using the neighbor-joining method, based on a 550-base pair pol fragment from SIV and HIV isolates. One isolate per each HIV-1 group M subtype was used. Branch lengths are drawn to scale (the bar indicates 10% divergence). The branches were estimated from 1,000 bootstrap replicates, and only bootstrap values of >80% are shown.
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