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Comment
. 2007 Jul 18;27(29):7617-8.
doi: 10.1523/JNEUROSCI.2353-07.2007.

Warming up the cold reception at a TRPM8 function

Wendy Y W Cheung  1 , Noo-Rie Ha, Michael W H Suen, Chen L Xu, Cheng Wei T Yang
Affiliations
Comment

Warming up the cold reception at a TRPM8 function

Wendy Y W Cheung et al. J Neurosci. .
No abstract available

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Figures

Figure 1.
Figure 1.
Overview of TRPM8 regulation, as proposed by Andersson et al. (2007). TRPM8 channels are activated by cold and chemical agonists, like icilin and menthol, producing an influx of Ca2+. These channels are also modulated by endogenous lipid agonists derived from glycerophospholipids via iPLA2. PUFAs act as negative modulators, whereas LPLs act as positive modulators. At equimolar concentrations of LPLs and PUFAs, there is net activation of TRPM8 channels, so inhibitors of iPLA2 such as ACA and BEL reduce TRPM8 activity.
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