Evaluation of brain tumor recurrence by (99m)Tc-tetrofosmin SPECT: a prospective pilot study
- PMID: 17634847
- DOI: 10.1007/s12149-007-0027-x
Evaluation of brain tumor recurrence by (99m)Tc-tetrofosmin SPECT: a prospective pilot study
Abstract
Objective: The differentiation between brain tumor recurrence and post-irradiation injury remains an imaging challenge. Computed tomography (CT) and magnetic resonance imaging (MRI) cannot always distinguish between the two. Although glioma cell line studies substantiated a plausible imaging superiority of (99m)Tc-tetrofosmin ((99m)Tc-TF) over other radiopharmaceuticals, little has been reported on its in vivo imaging properties. We assessed (99m)Tc-TF single-photon emission CT (SPECT) in cases where morphologic brain imaging was inconclusive between recurrence and radionecrosis.
Methods: A total of 11 patients (7 men, 4 women) were evaluated. The initial diagnosis was glioblastoma multiforme (4), anaplastic astrocytoma (1), anaplastic oligodendroglioma (3), grade-II astrocytoma (2), and low-grade oligodendroglioma (1). All patients had been operated on and then received adjuvant external-beam radiotherapy. After a mean follow-up period of 25 months, there was clinical suspicion of recurrence, for which (99m)Tc-TF SPECT was performed.
Results: In 8/11 cases, an abnormally increased tracer uptake appeared in the region that CT and/or MRI indicated as suspicious; in half of these cases, recurrence was confirmed histologically after surgery and in the other four by growth of the lesion over a 6-month follow-up period, and clinical deterioration. The remaining 3/11 patients had faint tracer uptake in the suspicious region, compatible with radiation injury; these lesions remained morphologically unaltered in a mean 12-month follow-up period, with no clinical deterioration in the patient's condition, a course strongly favoring the diagnosis of radiation injury.
Conclusions: Metabolic brain imaging by (99m)Tc-TF could offer useful information in the workup of treated brain tumors, where radiomorphologic findings between recurrence and radionecrosis are inconclusive.
Similar articles
-
Comparison of diffusion tensor, dynamic susceptibility contrast MRI and (99m)Tc-Tetrofosmin brain SPECT for the detection of recurrent high-grade glioma.Magn Reson Imaging. 2014 Sep;32(7):854-9. doi: 10.1016/j.mri.2014.04.013. Epub 2014 Apr 24. Magn Reson Imaging. 2014. PMID: 24848292 Clinical Trial.
-
Correlation of glioma proliferation assessed by flow cytometry with (99m)Tc-Tetrofosmin SPECT uptake.Clin Neurol Neurosurg. 2009 Dec;111(10):808-11. doi: 10.1016/j.clineuro.2009.08.009. Epub 2009 Sep 1. Clin Neurol Neurosurg. 2009. PMID: 19726126
-
Comparison between contrast-enhanced magnetic resonance imaging and technetium 99m glucohepatonic acid single photon emission computed tomography with histopathologic correlation in gliomas.J Comput Assist Tomogr. 2006 Sep-Oct;30(5):723-33. doi: 10.1097/01.rct.0000228154.58281.88. J Comput Assist Tomogr. 2006. PMID: 16954918 Clinical Trial.
-
[99mTc]sestamibi and [99mTc]tetrofosmin in oncology: SPET and fusion imaging in lung cancer, malignant lymphomas and brain tumors.Q J Nucl Med Mol Imaging. 2005 Jun;49(2):133-44. Q J Nucl Med Mol Imaging. 2005. PMID: 16010251 Review.
-
Imaging gliomas with positron emission tomography and single-photon emission computed tomography.Semin Nucl Med. 2003 Apr;33(2):148-62. doi: 10.1053/snuc.2003.127304. Semin Nucl Med. 2003. PMID: 12756647 Review.
Cited by
-
99mTc-Tetrofosmin SPECT for the detection of glioma recurrence.Eur J Nucl Med Mol Imaging. 2008 Aug;35(8):1571-2. doi: 10.1007/s00259-008-0824-z. Epub 2008 May 20. Eur J Nucl Med Mol Imaging. 2008. PMID: 18491087 No abstract available.
-
The role of 99mTc-tetrofosmin brain SPECT in differentiating treatment-induced necrosis from recurrent brain tumor.J Neurooncol. 2011 Sep;104(2):611. doi: 10.1007/s11060-010-0507-z. Epub 2010 Dec 28. J Neurooncol. 2011. PMID: 21188468 No abstract available.
-
Magnetic Resonance Spectroscopy and Single-Photon Emission Computed Tomography in the Evaluation of Cerebral Tumors: A Case Report.J Clin Med Res. 2017 Jan;9(1):74-78. doi: 10.14740/jocmr2775w. Epub 2016 Nov 24. J Clin Med Res. 2017. PMID: 27924180 Free PMC article.
-
Multiple occipital defects caused by arachnoid granulations: Emphasis on T2 mapping.World J Radiol. 2012 Jul 28;4(7):341-4. doi: 10.4329/wjr.v4.i7.341. World J Radiol. 2012. PMID: 22900137 Free PMC article.
-
Technetium Tc99m tetrofosmin single-photon emission CT for the assessment of glioma proliferation.AJNR Am J Neuroradiol. 2008 Nov;29(10):e96. doi: 10.3174/ajnr.A1183. AJNR Am J Neuroradiol. 2008. PMID: 19008320 Free PMC article. No abstract available.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous