Review
doi: 10.1042/BST0350686.
Astrocyte-leucocyte interactions and the mechanisms regulating matrix degradation in CNS tuberculosis
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- PMID: 17635122
- DOI: 10.1042/BST0350686
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Review
Astrocyte-leucocyte interactions and the mechanisms regulating matrix degradation in CNS tuberculosis
Biochem Soc Trans.
2007 Aug.
Abstract
The CNS (central nervous system) has a unique pattern of immune response to infection. TB (tuberculosis) of the CNS is devastating with widespread tissue destruction. In TB, astrocyte-leucocyte interactions are key in regulating MMP (matrix metalloproteinase) activity and are regulated by complex signalling pathways. A synergistic interaction between interferon gamma and monocyte-derived mediators drives high-level astrocyte MMP-9 secretion; this and other networking effects are inhibited by steroids. Better understanding of regulatory mechanisms may identify potential switch points that could be future therapeutic targets.
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