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. 1991 Sep;30(3):233-7.
doi: 10.1007/BF01610347.

[Transport of the hydroxy analogs of leucine in the brush border membrane vesicles of the rabbit small intestine]

[Article in German]
M Friedrich  1 , H Murer, E G Berger
Affiliations

[Transport of the hydroxy analogs of leucine in the brush border membrane vesicles of the rabbit small intestine]

[Article in German]
M Friedrich et al. Z Ernahrungswiss. 1991 Sep.

Abstract

Hydroxy analogues of essential amino acids can be used in clinical nutrition to minimize nitrogen intake. In this study intestinal uptake of L-leucine hydroxy analogue into rabbit jejunal brush-border membrane vesicles was investigated. An inward directed H(+)-gradient was a driving force of uptake (pHoutside = 6.0; pHinside = 7.5) and led to a transient accumulation. The saturable system has a apparent transport constant Kt = 15.4 mM. By trans stimulation experiments it could be shown that both D- and L-stereoisomers of hydroxy analogues of branched chain amino acids as well as L-lactate share with the same H(+)-driven uptake system.

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