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. 2007 Sep;4(5):1479-84.
doi: 10.1111/j.1743-6109.2007.00556.x. Epub 2007 Jul 17.

Long-acting intramuscular testosterone undecanoate for treatment of female-to-male transgender individuals

Jens W Jacobeit  1 , Louis J Gooren, Heinrich M Schulte
Affiliations

Long-acting intramuscular testosterone undecanoate for treatment of female-to-male transgender individuals

Jens W Jacobeit et al. J Sex Med. 2007 Sep.

Abstract

Aim: Testosterone treatment is essential for the induction and maintenance of virilization of female-to-male transsexuals. This study tested the suitability of a novel testosterone preparation for this purpose.

Methods: Parenteral long-acting testosterone undecanoate (TU) was administered to 12 female-to-male transsexuals. Observations were made while subjects received treatment.

Main outcome measures: Virilization of female-to-male transsexuals and side effects of testosterone administration.

Results: The testosterone levels were largely identical to those in hypogonadal men receiving testosterone treatment with TU. There were no side effects. There was a small but significant decrease in plasma cholesterol and low-density lipoprotein, but plasma high-density lipoprotein did not change significantly. Both levels of hemoglobin and hematocrit rose upon administration but remained within the physiological range.

Conclusions: TU is suited for induction of virilization in female-to-male transsexuals without significant side effects.

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