Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2007 Aug;130(2):223-4.
doi: 10.1085/jgp.200709829. Epub 2007 Jul 16.

Concerning tryptophan and protein-bilayer interactions

Comment

Concerning tryptophan and protein-bilayer interactions

Roger E Koeppe 2nd. J Gen Physiol. 2007 Aug.
No abstract available

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Maximum 2H-NMR quadrupolar splittings observed for deuterated indole rings in bilayers of DMPC, either “free” to diffuse within the lipid or attached to a membrane-spanning peptide. From left to right: “free” indole (from Persson et al., 1998), four tryptophans in WALP19, and Trp13 of gramicidin A (from van der Wel et al., 2007).

Comment on

References

    1. Dunbrack, R.L., Jr. 2002. Rotamer libraries in the 21st century. Curr. Opin. Struct. Biol. 12:431–440. - PubMed
    1. Durkin, J.T., L.L. Providence, R.E. Koeppe II, and O.S. Andersen. 1992. Formation of non-β6.3-helical gramicidin channels between sequence-substituted gramicidin analogues. Biophys. J. 62:145–159. - PMC - PubMed
    1. Hessa, T., H. Kim, K. Bihlmaier, C. Lundin, J. Boekel, H. Andersson, I. Nilsson, S.H. White, and G. von Heijne. 2005. Recognition of transmembrane helices by the endoplasmic reticulum translocon. Nature. 433:377–381. - PubMed
    1. Hu, W., K.C. Lee, and T.A. Cross. 1993. Tryptophans in membrane proteins: indole ring orientations and functional implications in the gramicidin channel. Biochemistry. 32:7035–7047. - PubMed
    1. Koeppe, R.E., II, J.A. Killian, and D.V. Greathouse. 1994. Orientations of the tryptophan 9 and 11 side chains of the gramicidin channel based on deuterium NMR spectroscopy. Biophys. J. 66:14–24. - PMC - PubMed

MeSH terms