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Comment
. 2007 Aug;130(2):237-40.
doi: 10.1085/jgp.200709850. Epub 2007 Jul 16.

Modeling charged protein side chains in lipid membranes

Comment

Modeling charged protein side chains in lipid membranes

Toby W Allen. J Gen Physiol. 2007 Aug.
No abstract available

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Free energy profiles for a protonated Arg side chain (solid red), protonated methyl-guanidinium (dashed red, symmetrized), and neutral Arg side chain (solid blue, symmetrized) with system images revealing membrane perturbations (lipid hydrocarbon, gray sticks; displaced lipid phosphorous atoms, yellow balls; displaced water, red/white balls; Arg, gray/blue balls; α-helix, green ribbons). Adapted from data in Li et al., 2007.

Comment on

References

    1. Bond, P.J., and M.S.P. Sansom. 2007. Bilayer deformation by the Kv channel voltage sensor domain revealed by self-assembly simulations. Proc. Natl. Acad. Sci. USA. 104:2631–2636. - PMC - PubMed
    1. Cymes, G.D., Y. Ni, and C. Grosman. 2005. Probing ion-channel pores one proton at a time. Nature. 438:975–980. - PMC - PubMed
    1. Dorairaj, S., and T.W. Allen. 2007. On the thermodynamic stability of a charged arginine side chain in a transmembrane helix. Proc. Natl. Acad. Sci. USA. 104:4943–4948. - PMC - PubMed
    1. Freites, J.A., D.J. Tobias, G. von Heijne, and S.H. White. 2005. Interface connections of a transmembrane voltage sensor. Proc. Natl. Acad. Sci. USA. 102:15059–15064. - PMC - PubMed
    1. Grabe, M., H. Lecar, Y. Jan, and L. Jan. 2004. A quantitative assessment of models for voltage-dependent gating of ion channels. Proc. Natl. Acad. Sci. USA. 101:17640–17645. - PMC - PubMed