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. 2007 Aug;3(8):442-6.
doi: 10.1038/nchembio0807-442.

Scaffold composition and biological relevance of screening libraries

Anang A Shelat  1 , R Kiplin Guy
Affiliations

Scaffold composition and biological relevance of screening libraries

Anang A Shelat et al. Nat Chem Biol. 2007 Aug.

Abstract

The chemical scaffolds from which screening libraries are built have strong influence on the libraries' utility for screening campaigns. Here we present analysis of the scaffold composition of several types of commercially available screening collections and compare those compositions to those of drugs and drug candidates.

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