The effects of piracetam on morphine-induced amnesia and analgesia: the possible contribution of central opiatergic mechanisms on the antiamnestic effect of piracetam
- PMID: 17638127
- DOI: 10.1007/s10787-998-0006-4
The effects of piracetam on morphine-induced amnesia and analgesia: the possible contribution of central opiatergic mechanisms on the antiamnestic effect of piracetam
Abstract
The involvement of opiatergic mechanisms on the antiamnestic effects of piracetam was investigated in mice. First, the effects of piracetam and naloxone on the amnesia induced by scopolamine, electroconvulsive shock and morphine were evaluated by using elevated plus maze apparatus. Second, the effects of electroconvulsive shock and piracetam on the antinociceptive action of morphine were tested by means of radiant heat tail-flick experiment. Piracetam and naloxone reversed the drug- or electrically-induced amnestic effects. On the other hand, electroconvulsive shock treatment enhanced the antinociceptive effect of morphine while piracetam decreased the same activity. These results suggest an important role of the opiatergic system on the learning and memory process as well as on the antiamnestic effect of piracetam.
Similar articles
-
Effect of piracetam and of standardized ginseng extract on the electroconvulsive shock-induced memory disturbances in "step-down" passive avoidance.Acta Physiol Pharmacol Bulg. 1987;13(2):11-7. Acta Physiol Pharmacol Bulg. 1987. PMID: 3673597
-
Specificity of piracetam's anti-amnesic activity in three models of amnesia in the mouse.Pharmacol Biochem Behav. 1988 Mar;29(3):625-9. doi: 10.1016/0091-3057(88)90030-5. Pharmacol Biochem Behav. 1988. PMID: 3362958
-
Comparative studies on the effects of the nootropic drugs adafenoxate, meclofenoxate and piracetam, and of citicholine on scopolamine-impaired memory, exploratory behavior and physical capabilities (experiments on rats and mice).Acta Physiol Pharmacol Bulg. 1988;14(1):3-13. Acta Physiol Pharmacol Bulg. 1988. PMID: 3136617
-
Nootropic drugs and brain cholinergic mechanisms.Prog Neuropsychopharmacol Biol Psychiatry. 1989;13 Suppl:S77-88. doi: 10.1016/0278-5846(89)90112-7. Prog Neuropsychopharmacol Biol Psychiatry. 1989. PMID: 2694231 Review.
-
Piracetam and other structurally related nootropics.Brain Res Brain Res Rev. 1994 May;19(2):180-222. doi: 10.1016/0165-0173(94)90011-6. Brain Res Brain Res Rev. 1994. PMID: 8061686 Review.