doi: 10.1007/s00128-007-9226-3.
Epub 2007 Jul 17.
Effect of selenium pretreatment in chronic mercury intoxication in rats
Affiliations
- PMID: 17639317
- DOI: 10.1007/s00128-007-9226-3
Item in Clipboard
Effect of selenium pretreatment in chronic mercury intoxication in rats
Bull Environ Contam Toxicol.
2007 Sep.
Abstract
Effect of selenium pretreatment (0.2 mg/kg/day, as sodium selenite), 4 h prior to mercury treatment (0.4 mg/kg/day, as mercuric chloride), administered intraperitoneally, was examined after daily exposure for 20 days' in rats. Liver, kidney and brain tissues were assayed for malondialdehyde (MDA) level, glutathione (GSH) content and mercury concentration. Mercury induced MDA levels, which was also observed in selenium pretreated animals. Significant reduction in GSH levels was observed in mercury alone and selenium pretreated animals. Mercury accumulation was in the order of kidney, liver and brain. Selenium pretreatment resulted in further enhancement in mercury accumulation in liver and kidney.
Similar articles
-
The interaction of selenium and mercury in the accumulations and oxidative stress of rat tissues.Ecotoxicol Environ Saf. 2008 Jul;70(3):483-9. doi: 10.1016/j.ecoenv.2007.05.018. Epub 2007 Jul 20. Ecotoxicol Environ Saf. 2008. PMID: 17644179
-
Depletion of glutathione in the kidney and the renal disposition of administered inorganic mercury.Drug Metab Dispos. 1997 Apr;25(4):516-23. Drug Metab Dispos. 1997. PMID: 9107552
-
Evaluation of comparative effect of pre- and posttreatment of selenium on mercury-induced oxidative stress, histological alterations, and metallothionein mRNA expression in rats.J Biochem Mol Toxicol. 2010 Mar-Apr;24(2):123-35. doi: 10.1002/jbt.20320. J Biochem Mol Toxicol. 2010. PMID: 20143455
-
Effect of interaction between 65Zn, mercury and selenium in rats (retention, metallothionein, endogenous copper).Arch Toxicol. 1983 Jun;53(2):165-75. doi: 10.1007/BF00302724. Arch Toxicol. 1983. PMID: 6224476 Review.
-
Analytical and bioanalytical approaches to unravel the selenium-mercury antagonism: a review.Anal Chim Acta. 2013 Nov 1;801:1-13. doi: 10.1016/j.aca.2013.08.043. Epub 2013 Aug 31. Anal Chim Acta. 2013. PMID: 24139569 Review.
Cited by
-
Radioprotective Effect of Selenium Nanoparticles: A Mini Review.IET Nanobiotechnol. 2024 Jan 25;2024:5538107. doi: 10.1049/2024/5538107. eCollection 2024. IET Nanobiotechnol. 2024. PMID: 38863968 Free PMC article.
-
Thyroid hormones and methylmercury toxicity.Biol Trace Elem Res. 2008 Winter;126(1-3):1-12. doi: 10.1007/s12011-008-8199-3. Epub 2008 Aug 22. Biol Trace Elem Res. 2008. PMID: 18716716 Free PMC article. Review.
-
Oxidant balance in brain of rats receiving different compounds of selenium.Biometals. 2013 Oct;26(5):763-71. doi: 10.1007/s10534-013-9654-y. Epub 2013 Jul 10. Biometals. 2013. PMID: 23839117 Free PMC article.
-
Biosynthesis of selenium nanoparticles and their protective, antioxidative effects in streptozotocin induced diabetic rats.Sci Technol Adv Mater. 2020 Jul 27;21(1):505-514. doi: 10.1080/14686996.2020.1788907. Sci Technol Adv Mater. 2020. PMID: 32939175 Free PMC article.
-
Selenium Nanoparticles: Green Synthesis and Biomedical Application.Molecules. 2023 Dec 15;28(24):8125. doi: 10.3390/molecules28248125. Molecules. 2023. PMID: 38138613 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
