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. 2007 Dec;21(12):1251-2.
doi: 10.1002/ptr.2236.

COX-1 and -2 activity of rose hip

A K Jäger  1 , I M S Eldeen, J van Staden
Affiliations

COX-1 and -2 activity of rose hip

A K Jäger et al. Phytother Res. 2007 Dec.

Abstract

The objective of this study was to investigate whether the clinically observed efficacy of rose hip in the treatment of osteoarthritis is due to inhibition of cyclooxygenase-1 and -2. Water, methanol, dichloromethane and hexane extracts of rose hip were tested for in vitro COX-1 and 2 activity. The organic solvent extracts showed good inhibition of both COX-1 and 2. The methanol extract was most active in both assays with IC(50) values of 12 microg/mL for COX-1 and 19 microg/mL for COX-2. The clinically observed effect might be due to inhibition of cyclooxygenase.

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