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. 2007 Sep-Oct;19(5):692-702.
doi: 10.1002/ajhb.20660.

Genetic and environmental influences on infant weight and weight change: the Fels Longitudinal Study

Ellen W Demerath  1 , Audrey C Choh, Stefan A Czerwinski, Miryoung Lee, Shumei S Sun, Wm Cameron Chumlea, Dana Duren, Richard J Sherwood, John Blangero, Bradford Towne, Roger M Siervogel
Affiliations

Genetic and environmental influences on infant weight and weight change: the Fels Longitudinal Study

Ellen W Demerath et al. Am J Hum Biol. 2007 Sep-Oct.

Abstract

Despite significant progress in understanding the mechanisms by which the prenatal/maternal environment can alter development and adult health, genetic influences on normal variation in growth are little understood. This work examines genetic and nongenetic contributions to body weight and weight change during infancy and the relationships between weight change and adult body composition. The dataset included 501 white infants in 164 nuclear and extended families in the Fels Longitudinal Study, each with 10 serial measures of weight from birth to age 3 years and 232 with body composition data in mid-adulthood. Heritability and covariate effects on weight and weight z-score change from birth to 2 years of age were estimated using a maximum likelihood variance decomposition method. Additive genetic effects explained a high proportion of the variance in infant weight status (h2=0.61-0.95), and change in weight z-score (h2=0.56-0.82). Covariate effects explained 27% of the phenotypic variance at 0-1 month of age and declined in effect to 6.9% of phenotypic variance by 36 months. Significant sex, gestational age, birth order, birth year, and maternal body mass index effects were also identified. For both sexes, a significant increase in weight z-score (>2 SD units) (upward centile crossing) was associated with greater adulthood stature, fat mass, and percent body fat than decrease or stability in weight z-score. Understanding genetic influences on growth rate in a well-nourished, nutritionally stable population may help us interpret the causes and consequences of centile crossing in nutritionally compromised contexts.

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Figures

Fig. 1
Fig. 1
Weight from 0 to 36 months, Fels longitudinal study, N = 501.
Fig. 2
Fig. 2
Phenotypic correlations between maternal BMI and offspring weight from 0 to 36 months by sex; N = 383, asterisks (*) indicate correlations that are significantly different from 0.0, P < 0.05.
Fig. 3
Fig. 3
Sex-adjusted genetic correlations (±SE) between weight at birth and subsequent weight measures, Fels longitudinal study, N = 501.
See this image and copyright information in PMC

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