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. 1976 Mar;56(3):671-3.
doi: 10.1093/jnci/56.3.671.

Malignant transformation of hamster brain cells in vitro by human papovavirus Bk

R Tanaka, H Koprowski, Y Iwasaki

Malignant transformation of hamster brain cells in vitro by human papovavirus Bk

R Tanaka et al. J Natl Cancer Inst. 1976 Mar.

Abstract

Human papovavirus BK caused the malignant transformation in vitro of brain cells prepared from newborn hamsters. The transformed cells produced BK virus T antigen and grew as tumors after sc inoculation ito hamsters that developed antibodies to BK virus T antigen. The histopathology of the tumors revealed an undifferentiated glioma.

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