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Case Reports
. 2007 Aug;38(8):1282-8.
doi: 10.1016/j.humpath.2007.03.008.

Malignant mixed mullerian tumor of the vagina: case report with review of the literature, immunohistochemical study, and evaluation for human papilloma virus

Matjaz Sebenik  1 , Zhijije Yan, Walid E Khalbuss, Khush Mittal
Affiliations
Case Reports

Malignant mixed mullerian tumor of the vagina: case report with review of the literature, immunohistochemical study, and evaluation for human papilloma virus

Matjaz Sebenik et al. Hum Pathol. 2007 Aug.

Abstract

The patient was a 57-year-old white woman who presented with a 3.0 x 2.0-cm partially ulcerated vaginal polyp. Histology revealed a malignant mixed mullerian tumor composed of invasive squamous cell carcinoma with deeper areas of undifferentiated pleomorphic sarcoma. Invasive carcinoma had overlying high-grade vaginal intraepithelial neoplasia (VaIN III), which contained koilocytic atypia. In situ hybridization detected high-risk human papillomavirus DNA in both the carcinoma and the sarcoma components.

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