Towards our understanding of SARS-CoV, an emerging and devastating but quickly conquered virus

doi:10.1016/j.cimid.2007.05.009

Review

. 2007 Sep;30(5-6):309-27.

doi: 10.1016/j.cimid.2007.05.009. Epub 2007 Jul 19.

Towards our understanding of SARS-CoV, an emerging and devastating but quickly conquered virus

Youjun Feng¹, George F Gao

Affiliations

PMID: 17640731
PMCID: PMC7112560
DOI: 10.1016/j.cimid.2007.05.009

Review

Towards our understanding of SARS-CoV, an emerging and devastating but quickly conquered virus

Youjun Feng et al. Comp Immunol Microbiol Infect Dis. 2007 Sep.

. 2007 Sep;30(5-6):309-27.

doi: 10.1016/j.cimid.2007.05.009. Epub 2007 Jul 19.

Authors

Youjun Feng¹, George F Gao

Affiliation

¹ Center for Molecular Virology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, China.

PMID: 17640731
PMCID: PMC7112560
DOI: 10.1016/j.cimid.2007.05.009

Abstract
in English, French

Severe acute respiratory syndrome (SARS) is a newly emerging infectious disease caused by a novel coronavirus (SARS-CoV), which has overwhelmed more than 30 countries claiming nearly 8400 cases with over 800 fatalities. Thanks to the unprecedented international collaboration, the whole-genomes of SARS-CoVs were successfully deciphered shortly after the identification of the causative pathogen for outbreak of SARS in southern China, in 2003. Hitherto, the SARS-CoV, as a viral paradigm of emerging infectious entities, has been extensively studied that has ranged from epidemiology, molecular virology/immunology to structural genomics. Also, several lines of breakthroughs have been record-brokenly obtained, that included the finding of ACE2, a functional receptor for the SARS-CoV, solution of the 3CL(pro) structure, a first crystal structure of SARS-related macromolecules, revealing of bats as natural reservoirs for SARS-like viruses and the possible involvement of civet cats in the SARS emergence. This review intends to outline the major progress in the journey of SARS-related exploration, by emphasizing those inaugurated studies with milestone-like significance contributed by Chinese research groups.

Le syndrome respiratoire aigu sévère (SRAS ou SARS), une maladie infectieuse émergeante causée par un nouveau coronavirus (SARS-CoV), toucha plus de 8400 personnes causant 800 morts dans 30 pays différents. Grâce à la mise en place d’une collaboration internationale sans précédent le décryptage du génome complet du SARS-CoV fut réalisé très peu de temps après l’identification de l’agent pathogène suite au déclenchement de l’épidémie dans le sud de la Chine en 2003. Le SARS-CoV en temps que paradigme de maladies infectieuses émergeantes a fait l’objet d’une étude complète en passant de l’épidémiologie, la virologie/immunologie moléculaire à la génomique structurale. Ainsi, c’est en un temps record qu’ont été obtenues des données majeures incluant la découverte de ACE2, un récepteur fonctionnel pour le SARS-CoV, la structure du 3CL^pro première structure cristallographique d’une macromolécule du SARS, révélant que la chauve-souris était le réservoir naturel de virus du type SARS, et que la civette était certainement à l’origine de l’émergence du SRAS. Cette revue vise à souligner les progrès majeurs réalisés dans l’exploration du SRAS, en soulignant l’importance des travaux primordiaux et précoces réalisés par les chercheurs chinois.

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Figures

**Fig. 1**
Characterization of the SARS-CoV. (A) Genomic structure of the SARS-CoV. (B) Schematic representation of the SARS-CoV virion. (C) Phylogenetic tree showing the relationships among the members of *Family Coronaviridae* based on the amino acid sequences of the spike proteins. MHV, HCoV-OC43, and BCoV belong to Group I of coronavirus, FIPV, TGEV, HCoV-229E, and SARS-CoV are classified into Group II of coronavirus. The SARS-CoV was highlighted in red. IBV forms an independent unique group, Group III. MHV, mouse hepatitis virus; HCoV-OC43, human coronavirus isolate OC43; BCoV, bovine coronavirus; FIPV, feline infectious peritonitis virus; TGEV, transmissible gastroenteritis virus; HCoV-229E, human coronavirus isolate 229E; IBV, infectious bronchitis virus.

**Fig. 2**
Landmark events in the SARS-related research field.

See this image and copyright information in PMC

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References

1. Berger A., Drosten C., Doerr H.W., Sturmer M., Preiser W. Severe acute respiratory syndrome (SARS)—paradigm of an emerging viral infection. J Clin Virol. 2004;29:13–22. - PMC - PubMed
1. Drosten C., Gunther S., Preiser W., van der Werf S., Brodt H.R., Becker S. Identification of a novel coronavirus in patients with severe acute respiratory syndrome. N Engl J Med. 2003;348:1967–1976. - PubMed
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[1] Berger A., Drosten C., Doerr H.W., Sturmer M., Preiser W. Severe acute respiratory syndrome (SARS)—paradigm of an emerging viral infection. J Clin Virol. 2004;29:13–22. - PMC - PubMed

[2] Berger A., Drosten C., Doerr H.W., Sturmer M., Preiser W. Severe acute respiratory syndrome (SARS)—paradigm of an emerging viral infection. J Clin Virol. 2004;29:13–22. - PMC - PubMed

[3] Drosten C., Gunther S., Preiser W., van der Werf S., Brodt H.R., Becker S. Identification of a novel coronavirus in patients with severe acute respiratory syndrome. N Engl J Med. 2003;348:1967–1976. - PubMed

[4] Drosten C., Gunther S., Preiser W., van der Werf S., Brodt H.R., Becker S. Identification of a novel coronavirus in patients with severe acute respiratory syndrome. N Engl J Med. 2003;348:1967–1976. - PubMed

[5] Guan Y., Zheng B.J., He Y.Q., Liu X.L., Zhuang Z.X., Cheung C.L. Isolation and characterization of viruses related to the SARS coronavirus from animals in southern China. Science. 2003;302:276–278. - PubMed

[6] Guan Y., Zheng B.J., He Y.Q., Liu X.L., Zhuang Z.X., Cheung C.L. Isolation and characterization of viruses related to the SARS coronavirus from animals in southern China. Science. 2003;302:276–278. - PubMed

[7] Ksiazek T.G., Erdman D., Goldsmith C.S., Zaki S.R., Peret T., Emery S. A novel coronavirus associated with severe acute respiratory syndrome. N Engl J Med. 2003;348:1953–1966. - PubMed

[8] Ksiazek T.G., Erdman D., Goldsmith C.S., Zaki S.R., Peret T., Emery S. A novel coronavirus associated with severe acute respiratory syndrome. N Engl J Med. 2003;348:1953–1966. - PubMed

[9] Liu W., Tang F., Fontanet A., Zhan L., Wang T.B., Zhang P.H. Molecular epidemiology of SARS-associated coronavirus, Beijing. Emerg Infect Dis. 2005;11:1420–1424. - PMC - PubMed

[10] Liu W., Tang F., Fontanet A., Zhan L., Wang T.B., Zhang P.H. Molecular epidemiology of SARS-associated coronavirus, Beijing. Emerg Infect Dis. 2005;11:1420–1424. - PMC - PubMed

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Towards our understanding of SARS-CoV, an emerging and devastating but quickly conquered virus

Affiliation

Towards our understanding of SARS-CoV, an emerging and devastating but quickly conquered virus

Authors

Affiliation

Abstract
in English, French

Figures

Similar articles

Cited by

References

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Miscellaneous

Abstract in English, French

Figures

Similar articles

Cited by

References

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Miscellaneous

Abstract
in English, French