Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2007 May;125(5):619-32.

Burden of disease & molecular epidemiology of group A rotavirus infections in India

Sasirekha Ramani  1 , Gagandeep Kang
Affiliations
Review

Burden of disease & molecular epidemiology of group A rotavirus infections in India

Sasirekha Ramani et al. Indian J Med Res. 2007 May.

Abstract

Rotavirus is the major cause of severe dehydrating diarrhoea in young children worldwide. Considerable research has been carried out on rotavirus disease in India. This review collated data from 46 epidemiological studies to determine rotavirus positivity rates and genotypes of infecting rotavirus strains from various settings in India. Studies on diarrhoea presenting to hospitals, neonatal rotavirus infections, symptomatic and asymptomatic infections in the community and nosocomial enteric infections were included. Rotavirus positivity rates varied greatly between different settings - diarrhoea hospitalizations (20%), neonatal infections (35%), symptomatic and asymptomatic infections in the community (15.1% and 6.3% respectively) and nosocomial enteric infections (22.5%). Among diarrhea hospitalizations, the commonest G types were G1 and G2 while commonest P types were P[8], P[6] and P[4]. Region specific neonatal infections by bovinehuman reassortants have been reported, in addition to several recently described unusual strains, which may be evidence of zoonotic infection and/or reassortment. The emergence of several new strains highlights the need for intensive strain surveillance before and after the introduction of a new vaccine.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Structure of rotavirus. Coding assignments of 11 RNA segment (left) and schematic diagram of ratavirus (right).
Fig. 2
Fig. 2
Overall distribution of G types in India (studies from 1990-2004). [Source: Table II].
Fig. 3
Fig. 3
Overall distribution of P types in India (studies from 1990-2004). [Source: Table III].
See this image and copyright information in PMC

References

    1. Prasad BVV, Estes MK. Electron cryomicroscopy and computer image processing techniques: use in structure-function studies of rotavirus. In: Gray JJ, Desselberger U, editors. Rotavirus methods and protocols. New Jersey: Humana Press; 2000. pp. 9–32. - PubMed
    1. Parashar UD, Gibson GJ, Bresee JS, Glass RI. Rotavirus and severe childhood diarrhea. Emerg Infect Dis. 2006;12:304–6. - PMC - PubMed
    1. Murphy TV, Gargiullo PM, Massoudi MS, Nelson DB, Jumaan AO, Okoro CA, et al. Intussusception among infants given an oral rotavirus vaccine. N Engl J Med. 2001;344:564–72. - PubMed
    1. Glass RI, Parashar UD. The promise of new rotavirus vaccines. N Engl J Med. 2006;354:75–7. - PubMed
    1. Vesikari T, Clark HF, Offit PA, Dallas MJ, Distefano DJ, Goveia MG, et al. Safety and efficacy of a pentavalent human-bovine (WC3) reassortant rotavirus vaccine. N Engl J Med. 2006;354:23–33. - PubMed

Publication types