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. 2003 Jul-Sep;21(3):196-8.

Emergence of low level vancomycin resistance in MRSA

S Assadullah  1 , D K Kakru, M A Thoker, F A Bhat, N Hussain, A Shah
Affiliations
  • PMID: 17643019

Emergence of low level vancomycin resistance in MRSA

S Assadullah et al. Indian J Med Microbiol. 2003 Jul-Sep.

Abstract

One hundred and twenty methicillin resistant Staphylococcus aureus (MRSA) strains were checked for minimum inhibitory concenteration (MIC) of vancomycin. The results showed that 98 strains (81.7 %) had MIC < 4microg/mL, 18 strains (15 %) had MIC 8 microg/mL, and 4 (03.3%) had MIC 16 microg/mL which being borderline between sensitive (< 4microg/mL) and resistant (>32 microg/mL) values points towards possible emergence of low level vancomycin resistance in the organisms and may explain the reasons of delayed therapeutic success of vancomycin in S. aureus bacteraemia in some situations.

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