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Review
. 2007 Oct;19(5):516-21.
doi: 10.1016/j.coi.2007.05.005. Epub 2007 Jul 20.

Apoptosis and the homeostatic control of immune responses

David Hildeman  1 , Trine Jorgensen, John Kappler, Philippa Marrack
Affiliations
Review

Apoptosis and the homeostatic control of immune responses

David Hildeman et al. Curr Opin Immunol. 2007 Oct.

Abstract

Normal homeostasis of the immune system is controlled by a balance of production and death. During an immune response, homeostasis is disturbed as antigen-presenting cells become activated and promote the clonal expansion of antigen-specific lymphocytes. Shortly after the peak of the response, controlled induction of apoptosis, of both antigen-presenting cells and lymphocytes, restores homeostasis. This process is critical to ensure protective immunity and avoid lymphoid neoplasia and autoimmunity. Here, we will discuss recent developments in the molecular players underlying apoptotic control of immune system homeostasis.

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