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. 2007 Sep 1;17(17):4733-6.
doi: 10.1016/j.bmcl.2007.06.070. Epub 2007 Jun 27.

Application of multicomponent reactions to antimalarial drug discovery. Part 3: discovery of aminoxazole 4-aminoquinolines with potent antiplasmodial activity in vitro

Chitalu C Musonda  1 , Susan Little, Vanessa Yardley, Kelly Chibale
Affiliations

Application of multicomponent reactions to antimalarial drug discovery. Part 3: discovery of aminoxazole 4-aminoquinolines with potent antiplasmodial activity in vitro

Chitalu C Musonda et al. Bioorg Med Chem Lett. .

Abstract

The synthesis and antimalarial activity of a novel series of first generation 4-aminoquinoline-containing 2,4,5-trisubstituted aminoxazoles against two strains of the Plasmodium falciparum parasite in vitro is described. A number of compounds significantly more potent than the standard drug chloroquine were identified.

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