Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1976 Apr;18(1):1-6.
doi: 10.1128/JVI.18.1.1-6.1976.

DNA polymerase activities induced by polyoma virus infection of 3T3 mouse fibroblasts

M Närkhammar, G Magnusson

DNA polymerase activities induced by polyoma virus infection of 3T3 mouse fibroblasts

M Närkhammar et al. J Virol. 1976 Apr.

Abstract

Resting mouse 3T3 fibroblasts were stimulated to synthesize DNA either by infection with polyoma virus or by injection of fresh serum. Changes in the levels of DNA polymerase (alpha-, beta-, and gamma-enzymes) were measured in the cytoplasm and the cell nucleus. Both types of stimulation gave very similar increases for all three enzyme activities. In the cell nucleus, both alpha- and gamma-polymerases increased almost tenfold, whereas the beta-enzyme only was stimulated twofold. In the cytoplasm alpha- and gamma-polymerases increased two- to four-fold. Only insignificant amounts of the beta-enzyme were found in the cytoplasm.

PubMed Disclaimer

References

    1. Biochem J. 1956 Feb;62(2):315-23 - PubMed
    1. J Biol Chem. 1962 Feb;237:519-25 - PubMed
    1. J Biol Chem. 1951 Nov;193(1):265-75 - PubMed
    1. J Virol. 1975 Nov;16(5):1095-100 - PubMed
    1. J Biol Chem. 1975 Oct 10;250(19):7951-7 - PubMed

LinkOut - more resources